Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Bioengineering & Biotechnology
A new CRISPR/Cas9 system with high editing efficiency and fidelity
We identified a novel type II-A nuclease, FrCas9. It possesses comparable cutting efficiency to SpCas9 but with lower off-target effect. Furthermore, the specific 5'-NNTA-3' PAM enables FrCas9 to directly target the TATA-box to regulate gene expression.
The Importance of False Discovery Rate Control in Metabolomics
We establish a novel approach to expand the utilization of FDR estimation by providing an automated false-discovery-rate-controlled analysis for data-independent acquisition in metabolomics.
Developing a therapeutic RNA base editing platform
Wave was founded on the idea that controlling backbone stereochemistry has potential to improve chemically modified oligonucleotide therapeutics. We now report a stereopure RNA base editing platform, adding a new modality that can help us deliver transformational therapies for patients .
