Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Bioengineering & Biotechnology
A multiple electrochemical sensing fibre for long-term disease biomarkers monitoring in vivo
To fabricate a stable device-tissue interface, the bundles of carbon nanotubes fibres were twisted to form a hierarchical structure that mimic the native tissues. After modification, the sensing fibres could realize the long-term monitoring of multiple disease biomarkers in vivo.
Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces
Pharmaceutically important polyketides are produced during the stationary phase of growth of Streptomyces species in fermenters. The source of intracellular metabolites that are funneled into polyketide biosynthesis has proven elusive. We uncover the mystery and devised a titer improvement strategy.
Linking nanotechnology and microbiome for cancer therapy
Nanotechnologies and microbiome are both important fields in novel cancer therapy. Linking these two fields together, we asked what opportunities may exist? Our recent review discusses key opportunities in applying nanotechnologies towards manipulating the microbiome for cancer treatment.
Harnessing Type I CRISPR–Cas systems for genome engineering in human cells
Using a FokI fusion design, we show that Type I CRISPR-Cas systems can be expressed, reconstituted, and faithfully trafficked to the nucleus for genome engineering in human cells
Nanoparticle drug delivery targets an intracellular source of pain
With a need to develop new non-opioid analgesics, pH-responsive nanoparticles may offer an alternative strategy for improving analgesic drug efficacy and duration of action.
