Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Biomedical Research
Unlocking the power of investigative biopsies in glioma
Glioblastoma (GBM) is a primary brain cancer with a devastating prognosis with limited treatment options. Stereotactic biopsies are performed routinely for histological and molecular diagnosis, but could they also be performed for detailed multi-omics investigation into the tumor microenvironment?
SPECTRUM OF BRAF MUTATIONS IN PAKISTANI COHORT
MOTIVATION BEHIND THE STUDY
"BRAF mutations and the association of V600E with CD133 and CDX2 expression in a Pakistani colorectal carcinoma cohort " https://doi.org/10.1186/s12885-024-12925-z
Unraveling the Genetic Mysteries of Psychiatric Disorders
This study integrated genetic, exon-level transcriptomic and single-cell data, pinpointing 110 core genes and shared pathways like circadian rhythm, cortisol, and dopamine signaling. Affected genes are key in excitatory neurons in the prefrontal cortex, suggesting links to cognitive issues.
Pyroptosis as a Central Mechanism in Multisystem Toxicities Triggered by Environmental Pollutants
Pollution is bad for our health, but how exactly? Research says that one mechanism of cell death, pyroptosis, could be an important clue. Activated by pollutants, it leads to inflammation and damage to organs. To understand it can help us counteract pollution's long-term harm.
