Cancer Latency: Time for A New Definition
Our concept of cancer latency, the interval from when a cancer starts until it is diagnosed, has changed dramatically. A prior widely-used definition was the interval between an exposure to a cancer-causing substance and cancer diagnosis.
Looking for Multi-Biomarker Panel Signature in HER2-Negative Breast Cancer through TNM-Based Stages Using Systems Biology Techniques
Breast cancer as the second most common cause of death among women should be given an special attention for improving survival rates by considering early diagnosis and screening programmes. However, most of the patients with BC disease are diagnosed at late stages of the disease.
NGS-based IGHV SHM analysis in CLL
The most challenging part of NGS-based IGHV analysis in CLL concerns the interpretation of the findings rather than the analysis per se.
ERIC and EuroClonality-NGS are working hard on addressing open issues and on standardization. See Davi et al., Leukemia 2020, doi: 10.1038/s41375-020-0923-9.
Lesion Segregation
Pervasive lesion segregation shapes cancer genome evolution, a new paper from The Liver Cancer Evolution Consortium reveals fundamental insights into mutagenesis. The discovery shows how unrepaired DNA damage generates genetic diversity and provides unprecedented views of DNA repair processes.
Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
This project was a great human adventure and we hope that our work will facilitate awareness of the risks associated with shift work and all types of chronic circadian stress on health, in particular for the prevention and follow-up of cancers.
