ARID1A’s role in lineage plasticity and therapeutic response in breast cancer
We uncover a critical role for ARID1A in maintaining luminal cell identity and endocrine therapy response in ER+ breast cancer.
The Peter Pan syndrome: stalled development in pediatric brain tumors
We use a data-driven approach to identify cell of origin in several pediatric brain tumor entities, and show that tumor gene expression programs are consistent with stalled differentiation of the corresponding normal lineages
Conducting CRISPR/dCas9 screens to identify drug resistance mechanisms in neuroblastoma
To wait for resistance to drugs to develop in patients and then identify why it happened, will lead to a deadly lag in the design of salvage therapies or indeed preventative treatment approaches.
Negative selection and neoantigen depletion in the cancer genome: in search for what’s not there
In our latest manuscript we describe a systematic analysis of negative selection pressures acting on neoantigen forming mutations. Contrary to what is generally believed we did not find any clear evidence of this immunogenic form of selection and the resulting neoantigen depletion.
Connecting the dots: adapting innovative antibody technology to improve cancer immunotherapy
Turns out there are times when it’s important to improve on mother nature, especially when confronting a life-threatening disease.