Access to Both Prenylated and Reverse-Prenylated Indolines through Photocatalytic Dearomatization/Rearrangement of Electron-Deficient Indoles
A visible-light-induced Giese radical dearomatization/Ireland-Claisen rearrangement, provides an alternative approach to accomplish the valuable prenylation and reverse-prenylation of electron-deficient indoles in good to excellent yields and diastereoselectivities.
Collective photothermal bending of flexible organic crystals modified with MXene-polymer multilayers as optical waveguide arrays
We present a straightforward approach to obtain flexible hybrid organic crystalline materials that are mechanically responsive to infrared light.
Unveiling the Role of Protein Glycosylation: Insights into Conformational Dynamics and Disease Mechanisms
Glycosylation plays a critical role in controlling normal cell functions as well as disease-related conditions. Understanding how sugar modifications impact proteins, including their conformations and interactions, is crucial for unraveling the causes of diseases and developing targeted treatments.
Structure-function analysis of a new type of amide bond forming enzyme
The condensation enzyme CcbD catalyzes an amide bond formation between the carrier protein-tethered proline and thiooctose in the biosynthesis of lincosamide antibiotics. Here, we report the structure-function analyses of CcbD by in vitro characterization, crystallization, and mutagenesis.
Direct Allylic Acylation via Cross-Coupling Involving Cooperative N‑Heterocyclic Carbene, Hydrogen Atom Transfer, and Photoredox Catalysis
We proposed a strategy that using carboxylic acids and readily available olefins as substrates for transformations involving N heterocyclic carbene catalysis, hydrogen atom transfer catalysis, and photoredox catalysis for the synthesis of β,γ-unsaturated ketones.
