Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: General & Internal Medicine
Loss of DOCK2 potentiates Inflammatory Bowel Disease–associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression
In this paper we identify Dock2 as an immune regulator in IBD-CRC, with potential therapeutic opportunity in this area of unmet clinical need.
Digestive and molecular adaptations for extreme blood glucose regulation in nectar and fruit bats (Chiroptera, Phyllostomidae)
We discovered the duodenum is a crucial blood glucose regulator in the evolution of high-sugar diets. The adaptations result in blood glucose levels >750 mg/dL, the highest recorded in mammals. This indicates new possibilities to improve glycemic control in the human diabetes epidemic.
Unlocking the Power of Deep Learning for Multi-Omic Molecular Profiling: Insights from a Pan-Cancer Study
We investigated the capability of deep learning (DL) for molecular profiling using routine pathology images. Distilling results from over 4,000 biomarkers, we found that DL can establish status of many biomarkers across multiple cancers, indicating its potential for revolutionising patient care.
