Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Healthcare & Nursing
GWAS for lung function with adjustment for exhaled nitric oxide levels as airway inflammation indicator
We performed a GWAS for lung function with adjustment for exhaled nitric oxide (FeNO) levels to account for type 2 airway inflammation. Our study identified the genetic locus most strongly associated with airway obstruction in the Japanese population and new genetic loci associated with FeNO.
When your body attacks itself – BTK inhibition shows promise for the treatment of chronic spontaneous urticaria (an autoimmune disease)
In a recent clinical trial, patients who had chronic spontaneous urticaria (CSU) for more than 6 months that would not respond to high doses of standard treatment (H1-antihistamines) – were enrolled to evaluate a “BTK blocker” drug, called, "fenebrutinib".
Normal-weight obesity in adolescents: a hidden problem
Normal-weight obesity is defined by the presence of normal weight according to the BMI, together with excess body fat. Although it is well recognized in the literature about the complications associated with BMI-defined obesity, few studies have evaluated normal-weight obesity in adolescents.
Fasting is required for the benefits of calorie restriction: The importance of when we eat
Restricting calorie intake extend lifespan and healthspan of many species, but the mechanism of how calorie restriction functions remains unclear. We show that prolonged fasting between meals imposed by such regimens may play a critical role in the benefits of reduced calorie diets.
An Unlikely Tale: How a Paper on Hemostasis, Puncture Wounds and Platelets Came from a Team Led by Ph.D.s in Physics and Biochemistry
Puncture wounds and how platelet leads to bleeding cessation is not normally thought of as problem in cell and developmental biology. Here a team trained in physics and biochemistry take exactly that approach to thrombus structure and how that leads to bleeding cessation in ta jugular wound.
SARS-CoV-2 variants of concern and possible future waves of infection
As the COVID-19 pandemic continues there is an ever-present risk of more variants of concern (VOCs) arising. These VOCs may have beneficial mutations aiding their spread. We used three mathematical models to examine the potential drivers of SARS-CoV-2 VOC epidemics in England.
