Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Microbiology
Jumping genes spark bacterial evolution
Transposable elements have been widely described to be crucial for eukaryotic evolution, from plant and animal colouration to mammalian lactation and pregnancy. However, their role in bacterial evolution is still puzzling.
Highly potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration
In one of our studies published in Nature Communications, we discover Nb457, an alpaca-derived nanobody with broad-spectrum anti-HIV-1 activity. Nb457 induces conformational changes in CD4, blocking viral entry. Its trimeric form achieves complete HIV-1 inhibition, promising treatments.
