Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Protocols & Methods
CRISPR Off-Targets: One SNP can make all the difference
In a recent paper, we used ultra-deep sequencing to determine whether CRISPR was introducing or enriching for mutations in cancer genes.
Sprod for De-noising Spatially Resolved Transcriptomics Data Based on Position and Image Information
Spatially resolved transcriptomics (SRTs) provide gene expression while retaining the locations of sequencing and providing matched pathology images; however, there are high levels of noise. We made Sprod to impute accurate SRT gene expression by leveraging their matched location and imaging data.
Describing the distribution of proteins on the cell surface
How can we quantify the nanoscale distribution of proteins on the cell surface? How can we tell if they are randomly distributed or not? The answer lies in a new data analysis method for single-molecule super-resolution microscopy.
