Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Fasting is required for the benefits of calorie restriction: The importance of when we eat
Restricting calorie intake extend lifespan and healthspan of many species, but the mechanism of how calorie restriction functions remains unclear. We show that prolonged fasting between meals imposed by such regimens may play a critical role in the benefits of reduced calorie diets.
The role of the stroma, encompassing pancreatic stellate cells and extracellular matrix, in the biology and chemoresistance of pancreatic cancer
Our report entitled “3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing” (PMID: 23446043) has its ten years anniversary. Herein we present the story "After the Paper" on the background of two recent publication from our group.
A protein hindered from folding by its parent ribosome
Cassaignau and colleagues use NMR to reveal how a dynamic elongating nascent polypeptide interacts with the ribosome to modulate its folding (https://www.nature.com/articles/s41557-021-00796-x)
