Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
A unified model for interpretable latent embedding of multi-sample, multi-condition single-cell data
The advent of single-cell technologies has allowed us not only to generate comprehensive atlases of cell types in their 'normal' states, but also to understand how these cells change under various conditions. Here, we introduce GEDI, a framework to enable the analysis of these datasets.
A high-resolution large-area detector for quality assurance in radiotherapy
This paper discusses the design, fabrication and performance tests of a detector based on Gas Electron Multipliers (GEM) coupled to a matrix of thin-film transistors (TFT).
Iridium nitrenoid-enabled arene C−H functionalization
Direct arene C−H functionalization via nucleophilic aromatic substitution remains a challenging task. Here we report an iridium nitrenoid-catalysed arene C−H functionalization strategy, making use of readily available aryl azides as electrophiles to react with different nucleophiles.
Highly potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration
In one of our studies published in Nature Communications, we discover Nb457, an alpaca-derived nanobody with broad-spectrum anti-HIV-1 activity. Nb457 induces conformational changes in CD4, blocking viral entry. Its trimeric form achieves complete HIV-1 inhibition, promising treatments.
Loss-induced quantum nonreciprocity
Here, we take a counterintuitive stance by engineering loss to generate a vital form of nonreciprocal quantum correlations, termed nonreciprocal photon blockade. we shown that a robust nonreciprocal single- and two-photon blockade can be achieve in a dissipative three-cavity system.
