Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
A PurFect strategy for tuberculosis drug discovery?
Tuberculosis treatment urgently needs new drugs targeting novel pathways. Here, we present a new compound which inhibits PurF, a key enzyme in purine biosynthesis. These findings offer a promising strategy to tackle drug-resistant TB and enhance the effectiveness of current treatment regimens.
From Mutation to Peptide: Resolving Proteome Complexity with moPepGen
A graph-based algorithm to detect variant peptides from the proteome—fast, flexible, and biologically faithful.
Unlocking the Molecular Mechanisms of BSEP Dysfunction: Toward Precision Therapies for PFIC2
From protein structure to precision medicine – how structural perturbations in a membrane protein may offer a blueprint to creating targeted therapies for a rare childhood genetic disease.
