Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Exploring SHANK3 in Neurodevelopment Using Stem Cells and Chemical Biology
Here we delve into our research on Phelan-McDermid syndrome (PMDS), a rare genetic disorder. We focused on SHANK3, an integral protein in neurodevelopment and synaptic function. We explore potential treatment strategies for PMDS, aiming to contribute to drug discovery in neurodevelopmental diseases.
PheSeq: How Bayesian Deep Learning Conceptualizes the Gene-Disease Associations and Bridges ’em with P-values?
"This study introduces PheSeq, a Bayesian deep learning model designed to integrate p-value data from sequence analysis with phenotype descriptions from literature and network data. It improves the robustness and interpretability of gene-disease association studies."
High-temperature superconductivity with zero resistance and strange-metal behaviour in a nickelate material
Evidence of high-temperature superconductivity under pressure was recently found in a bulk nickelate material, but zero-resistance was not seen. In a new study using a different high pressure technique, zero-resistance is revealed, as well as other clues for understanding the superconductivity.
Unveiling Single-Cell Resolution Insights into Epichaperomes in Tissues: Introducing the PU-TCO Clickable Epichaperome Probe
Discovering the secrets of neurodegenerative diseases and cancer at single-cell level precision - the PU-TCO clickable probe illuminates epichaperomes, offering insights into disease mechanisms at a cellular level.
