Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Targeting MYC with antisense oligonucleotides
The realization of direct-acting agents targeting the MYC oncogene has been a long-standing challenge in cancer therapeutics. Our recent paper describes new antisense tools with potent anti-MYC effects.
Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
Here we investigate the impact of different immune pressure on tumor clonal dynamics and immune evasion mechanism, by combining massive parallel sequencing of immune edited tumors and CRISPR library screens in syngeneic mouse tumor model and co-culture system.
