Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Overcoming immunotherapy resistance in melanoma defective of IFN-g signaling
Melanoma loss of IFN-g signaling is a major mechanism of resistance to immune checkpoint blockers such as anti-CTLA-4 and anti-PD-1, a prominent type of immunotherapies offering unprecedented therapeutic hopes to melanoma patients. However, strategies of overcoming this resistance have been elusive.
De novo-designed light-activated Reaction Centers pave the way toward new photosynthetic pathways
Proteins designed from scratch reproduce the multi-step electron transfer cascade that leads to charge separation in photosynthesis.
