Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Bioengineering & Biotechnology
First steps in a long journey: Understanding the potential clinical consequences of immune responses to the Cas9 protein
Recent demonstration of immune responses to Cas proteins identify a critical risk in the eventual clinical application of Cas-mediated gene editing. In the accompanying paper we extend these findings by identifying promiscuous T-cell epitopes on Cas9 derived from Staphylococcus aureus.
Accelerating Synthetic Biotic Development with Gut-on-a-chip Technology
M. Tyler Nelson & Mark R. Charbonneau--This article provides additional details on a successful collaboration between the 711th Human Performance Wing, Air Force Research Laboratory and Synlogic Inc., to develop human gut-on-a-chip models for screening high potential synbiotics.
Six Years for One Step Towards Unnatural Amino Acid–Controlled Gene Therapy
Stories behind the paper “Restoration of dystrophin expression in mice by suppressing a nonsense mutation through the incorporation of unnatural amino acids” that was recently published in Natural Biomedical Engineering.
