FOXQ1 utilizes the KMT2A/MLL complex as a transcriptional co-activator of EMT in breast cancer
Forkhead box Q1 (FOXQ1) recruits the KMT2A/MLL histone methyltransferase to gene regulatory regions by binding to RbBP5. In this study, we uncover the protein interaction mechanism and demonstrate how this transcriptional pathway could be exploited to suppress FOXQ1-mediated EMT and metastasis.
GRAMD1C-mediated cholesterol transport regulates autophagosome biogenesis and mitochondrial bioenergetics
In their study, Ng and coworkers identified the cholesterol transport protein GRAMD1C as a negative regulator of autophagy and mitochondrial bioenergetics and explored its link to Clear Cell Renal Carcinoma (ccRCC).
A liquid biopsy signature predicts lymph node metastases in T1 esophageal squamous cell carcinoma: implications for precision treatment strategy
The treatment strategies for T1 esophageal squamous cell carcinoma (ESCC) patients with or without lymph node metastasis (LNM) are different. We demonstrated that serum miR-20b-5p could predict LNM in T1 ESCC patients.
