Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Time is Precious
Our laboratory has been studying the long noncoding RNA ( lncRNA ) termed FIRRE for over 15 years and yet we have only recently realized we missed something critical: TIME. Time is precious and has changed the way we think about the entire field !
Unveiling the Mechanisms Behind Cancer Aggressiveness: How Epichaperomes Drive Cellular Plasticity
What makes cancer so aggressive and adaptable? Our latest research uncovers a hidden mechanism within cells—specialized protein networks called epichaperomes. These structures help cancer cells survive and thrive, reactivating developmental pathways and fueling unchecked growth.
Mutations may offer clues to cancer development in systemic sclerosis
The latest paper from Natalie Saini's group explores an intriguing connection between inflammation, DNA damage, and cancer via accrual of somatic mutations in patients of systemic sclerosis (scleroderma).
Visible light accelerates skin wound healing and alleviates scar formation in mice by adjusting STAT3 signaling
In mice keratinocytes, upregulation of PI3Kβ by red light promotes the p-STAT3 and accelerates skin wound healing by; ROS induced by blue light inhibits the p-STAT3 and alleviates scar formation.
Unravelling the bioactive potential of a bacterial symbiont of a tropical bird
Novel Amycolatopsis sp. PS_44_ISF1 isolated from the uropygial gland of Pachycephala schlegelii possesses the ability to produce a series of bioactive compounds, including two novel families of metabolites. Our study exemplifies the underexplored chemical potential of bacterial symbionts of birds.
Behind the paper: Untangling Zebrafish Genetic Annotation of TCOF1 and NOLC1
Our research journey began with an intriguing paradox: two genes, TCOF1 and NOLC1, critical for ribosomal RNA processing and nucleolar function, were confusingly annotated in zebrafish databases....
Enabling transport and metabolism in synthetic cells
Decarboxylation of L-malate coupled to L-malate/L-lactate exchange provides metabolic energy for the uptake and metabolism of nutrients in cell-like lipid vesicles.
Divalent and multivalent cations control liquid-like assembly of poly(ADP-ribosyl)ated PARP1 into multimolecular associates in vitro
We explain the role of poly(ADP-ribose) and biology relevant cations in the formation of condensates and points to the direct involvement of poly(ADP-ribosyl)ated PARP1 in the regulation of DNA repair via condensate formation.
