Behind the Paper

The real stories behind the latest research papers, from conception to publication, the highs and the lows

Filtered by: Cell & Molecular Biology
Nature Communications
Behind the Paper

Time is Precious

Our laboratory has been studying the long noncoding RNA ( lncRNA ) termed FIRRE for over 15 years and yet we have only recently realized we missed something critical: TIME. Time is precious and has changed the way we think about the entire field !
Go to the profile of John Rinn
John Rinn
Oct 21, 2024
Communications Chemistry
Behind the Paper

Photoreactive fragment pharmacophores explore potential binding sites and provide hits for highly challenging drug targets

Photoaffinity-tagged fragments are increasingly used for convenient hit detection and binding site mapping in early drug discovery. We tackled two important challenges by maximizing the pharmacophore diversity of the core fragments, and by enhancing the labelling efficiency of the photoaffinity tag.
Go to the profile of David Bajusz +1
David Bajusz and 1 other
Sep 11, 2024

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