Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Flexibility meets quality and scale
Finding solutions to all of these challenges was a major bottleneck for the burgeoning field of single-cell mass spectrometry proteomics.
PTMGPT2: An Interpretable Protein Language Model for Enhanced Post-Translational Modification Prediction
PTMGPT2 uses GPT-based architecture and prompt-based fine-tuning to predict post-translational modifications. It outperforms existing methods across 19 PTM types, offering interpretability and mutation analysis. This advances the understanding of protein function and disease research.
Exploring New Frontiers in Antifungal Therapy: The Essential Role of Vitamin B5 Metabolism
Fungal infections pose a significant global health threat, especially with the alarming rise in drug-resistant strains. Our study, published in Communications Biology, delves into groundbreaking research that could pave the way for novel therapeutic strategies against these pathogens.
De novo atomic protein structure modeling for cryoEM density maps
Cryo2Struct determines atomic structures of large proteins directly from cryo-EM density maps, advancing biomedical research and drug design.
Characterizing amphioxus development at the single-cell level: understanding chordate nervous system development
Our team uncovers new amphioxus central nervous system (CNS) cell types and we highlight three developmental origins for the vertebrate nervous system.
Dysfunctional Protein-Protein Interactome (dfPPI): A Platform for Systems-Level Analysis of PPI Alterations in Disease
Explore Dysfunctional Protein-Protein Interactome (dfPPI): Revealing how aberrant protein interactions drive cancer and neurodegeneration, guiding mechanistic insights and therapeutics innovations.
