Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Quantifying Cell-State Densities in Single-Cell Phenotypic Landscapes Using Mellon
What constitutes a tissue based on single-cell data and how can we represent it computationally? This question led us to develop Mellon, a tool to quantify cell-state densities and reveal dynamics of cell-differentiation processes. Here's a behind-the-scenes look at our journey.
Mycofluidics of clocks in single filaments of Neurospora crassa
We show single filaments in the model system Neurospora crassa have a biological clock. We also develop model of the clock in single filaments that is supported by microfluidics data and provides an explanation for long distance (mm) synchronization of clocks in filaments.
Exploring SHANK3 in Neurodevelopment Using Stem Cells and Chemical Biology
Here we delve into our research on Phelan-McDermid syndrome (PMDS), a rare genetic disorder. We focused on SHANK3, an integral protein in neurodevelopment and synaptic function. We explore potential treatment strategies for PMDS, aiming to contribute to drug discovery in neurodevelopmental diseases.
Unveiling Single-Cell Resolution Insights into Epichaperomes in Tissues: Introducing the PU-TCO Clickable Epichaperome Probe
Discovering the secrets of neurodegenerative diseases and cancer at single-cell level precision - the PU-TCO clickable probe illuminates epichaperomes, offering insights into disease mechanisms at a cellular level.
A new automated, multiplex approach to studying shear stress mechanotransduction of circulating cells
As the mechanobiology of immune and cancer cells is gaining interest, we developed an easy to adopt, off-the-shelf system for subjecting many different samples to repeated cycles of fluid shear stress.
Behind the paper: Unraveling the molecular mechanism behind COVID-19 pulmonary pathologies associated with ferroptosis
How we found that ferroptosis is a key driver of lung damage in severe COVID-19 patients,
By Baiyu Qiu, Fereshteh Zandkarimi, Anjali Saqi and Brent R. Stockwell