Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Epichaperomics: Illuminating the Secrets of Protein Interactions in Disease Research
Introducing Epichaperomics: an emerging omics platform for research to illuminate the secrets of diseases. By studying protein interactions in cells and tissues, it offers valuable insights into disease mechanisms and paves the way for personalized therapies.
Unveiling the Role of Protein Glycosylation: Insights into Conformational Dynamics and Disease Mechanisms
Glycosylation plays a critical role in controlling normal cell functions as well as disease-related conditions. Understanding how sugar modifications impact proteins, including their conformations and interactions, is crucial for unraveling the causes of diseases and developing targeted treatments.
CRISPR Off-Targets: One SNP can make all the difference
In a recent paper, we used ultra-deep sequencing to determine whether CRISPR was introducing or enriching for mutations in cancer genes.
Cornering the interactome to kill cancer cells
Joshi et al reveal how manipulating cancer cell protein-protein interactions networks (i.e. interactomes) eliminates rebound pathways, turning traditionally less effective therapeutics highly efficacious.
