Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
TSLPR CAR T-cell therapy: A new hope for CRLF2+ ALL, but timing of JAK inhibition is crucial
Acute lymphoblastic leukemia (ALL) with CRLF2 rearrangements in Ph-like and Down syndrome-associated ALL subtypes poses a significant challenge in pediatric oncology. These genetic abnormalities lead to constitutive signaling activation and induce resistance to conventional chemotherapy.
Dissecting the natural history of IDH-mutant gliomas
Our work reveals that as IDH mutant gliomas progress, their cell states and key drivers change.
Overcoming the Preferred Orientation Problem in CryoEM with spIsoNet
A self-supervised deep-learning method that offers a computational solution to preferred orientation problem in cryoEM.
Navigating New Territory in a Small Lab
The journey behind our recent paper was a long one, filled with hurdles and unexpected turns that we learned to navigate along the way. Working from a small lab with limited resources, we embarked on a project that introduced us to the complex and evolving field of biomolecular phase separation.
VEXAS Syndrome: Hope, Challenges, Solutions, and the Road Ahead
This post aims to raise awareness, build understanding, and inspire action within the medical and patient communities alike. The road is long, but with continued collaboration and innovation, we can offer new hope to those affected by VEXAS syndrome.
