Towards a molecular simulation-driven approach to polymer selection for drug formulation
Many drugs are poorly soluble in water and require suitable formulation for oral administration. The use of polymer excipients in amorphous solid dispersions of drugs has emerged as a promising strategy. This requires the identification of suitable polymers for the drug of interest.
Metal-free Photoinduced C(sp3)–H/C(sp3)–H Cross-Coupling to access α‑Tertiary Amino Acid Derivatives
The cross-dehydrogenative coupling (CDC) reaction is the most efficient method for constructing α-tertiary amino acids (ATAAs). Here, we present a mild, metal-free CDC reaction for the construction of ATAAs with good yields and regioselectivity.
