Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: General & Internal Medicine
Which algorithm is just right for my data?
Artificial intelligence is impacting research and drug discovery and such techniques have been developed and applied for decades for structure activity analysis. Yet the question of which algorithm to use and how many molecules are needed is still an open one. We found a Goldilocks zone may apply.
Exploring SHANK3 in Neurodevelopment Using Stem Cells and Chemical Biology
Here we delve into our research on Phelan-McDermid syndrome (PMDS), a rare genetic disorder. We focused on SHANK3, an integral protein in neurodevelopment and synaptic function. We explore potential treatment strategies for PMDS, aiming to contribute to drug discovery in neurodevelopmental diseases.
New tricks from old drugs: repurposing the 80s
A paper in Molecular Psychiatry describes a new cell biological mechanism regulated by antidepressants, showing how a single dose of a drug fluvoxamine may open up the brain for drug delivery. Can this finding signal the beginning of a brand new career for the 30+ year-old drugs?
