Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Healthcare & Nursing
Normal-weight obesity in adolescents: a hidden problem
Normal-weight obesity is defined by the presence of normal weight according to the BMI, together with excess body fat. Although it is well recognized in the literature about the complications associated with BMI-defined obesity, few studies have evaluated normal-weight obesity in adolescents.
Fasting is required for the benefits of calorie restriction: The importance of when we eat
Restricting calorie intake extend lifespan and healthspan of many species, but the mechanism of how calorie restriction functions remains unclear. We show that prolonged fasting between meals imposed by such regimens may play a critical role in the benefits of reduced calorie diets.
An Unlikely Tale: How a Paper on Hemostasis, Puncture Wounds and Platelets Came from a Team Led by Ph.D.s in Physics and Biochemistry
Puncture wounds and how platelet leads to bleeding cessation is not normally thought of as problem in cell and developmental biology. Here a team trained in physics and biochemistry take exactly that approach to thrombus structure and how that leads to bleeding cessation in ta jugular wound.
SARS-CoV-2 variants of concern and possible future waves of infection
As the COVID-19 pandemic continues there is an ever-present risk of more variants of concern (VOCs) arising. These VOCs may have beneficial mutations aiding their spread. We used three mathematical models to examine the potential drivers of SARS-CoV-2 VOC epidemics in England.
Age-Dependent, Motor Cortex Selective TARDBP Demethylation Unlock the Mystery in Amyotrophic Lateral Sclerosis
Our paper indicates DNA demethylation of the autoregulatory region of TDP-43 interferes with the TDP-43 autoregulation resulting in increasing TDP-43. The DNA demethylation increases in the human motor cortex by age. The tissue-specific, age-dependent demethylation may underlie the nature of ALS.
