Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Iridium nitrenoid-enabled arene C−H functionalization
Direct arene C−H functionalization via nucleophilic aromatic substitution remains a challenging task. Here we report an iridium nitrenoid-catalysed arene C−H functionalization strategy, making use of readily available aryl azides as electrophiles to react with different nucleophiles.
Highly potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration
In one of our studies published in Nature Communications, we discover Nb457, an alpaca-derived nanobody with broad-spectrum anti-HIV-1 activity. Nb457 induces conformational changes in CD4, blocking viral entry. Its trimeric form achieves complete HIV-1 inhibition, promising treatments.
Loss-induced quantum nonreciprocity
Here, we take a counterintuitive stance by engineering loss to generate a vital form of nonreciprocal quantum correlations, termed nonreciprocal photon blockade. we shown that a robust nonreciprocal single- and two-photon blockade can be achieve in a dissipative three-cavity system.
A Fiber for Electrons: The First Waveguide for Charged Particles in Vacuum
Electrons are key to modern technology, but guiding them over long distances remains challenging. We present the first vacuum-based electron waveguide utilizing Lagrange points, allowing efficient, extended electron transport. This innovation can revolutionize particle physics and quantum computing.
