Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
From Orphan Receptor to Metastatic Catalyst: Unveiling the Role of GPR107 in Breast Cancer Progression
GPR107 orchestrates breast cancer metastasis through a β-arrestin/ERK/STAT3 signaling axis that coordinately dismantles the collagen IV barrier via enhanced degradation, Clathrin-mediated endocytosis, and transcriptional suppression.
How Post-Translational Modifications Rewire Cellular Networks Through Epichaperomes
Proteins rarely work alone. Their functions emerge from networks of interactions—dynamic connections that continuously reorganize to maintain cellular balance. But what happens when this balance is lost?
When Silence Speaks: How BRCA1 Hypermethylation Fuels Sporadic Breast Cancers
Targeted promoter hypermethylation of BRCA1 uncovers how epigenetic silencing integrates transcriptional repression, hormonal adaptation, and immune modulation to reshape tumor identity.
