Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Stabilizing a cell state to restore immune recognition
In PDAC, tumor plasticity drives immune evasion and resistance. We show that MEKi induces GATA6-dependent MHCI upregulation in classical cells but also promotes loss of this immune-permissive state. Stabilizing GATA6 via HDACi preserves antigen presentation and boosts CD8⁺ T cell responses.
Cd₃As₂ Kinetic Inductance for Miniaturized Terahertz Circuits
Terahertz technologies and integrated systems remain constrained by geometry-dependent inductors. Cd₃As₂ spiral inductors harness giant kinetic inductance to enable compact, low-loss THz components and provide a scalable materials-driven route for next-generation on-chip circuits.
From “Weak” to “Tingling”: Measuring Just-Noticeable Differences in Whole-Body Vibration
Whole-body vibration (WBV) is used everywhere. Engineers can precisely control physical parameters such as vibration level, frequency, modulation rate, bandwidth, and decay. Yet users use qualitative words like weak, tingling, up-and-down, repetitive, even, or fading.
Did Domestication Reshape the Aging Brain? What Dogs—and Wolves—May Reveal About Alzheimer’s Vulnerability
Did domestication reshape brain aging? Comparing domestic dogs and gray wolves, we found that neurodegeneration-associated risk factors were more pronounced in dogs, suggesting that domestication and modern environments may have shifted vulnerability to cognitive decline.
Beyond the Battlefield: Simulating the Adaptive Dance of Modern War
Modern wars aren't just about force; they are about adaptation. Using smart computations, we show how attackers and defenders in the Russia-Ukraine conflict "learn" in real-time and found that the side that adapts fastest to protect and repair vital infrastructure wins the long-term strategic edge.
Behind the Paper: A Guide to Transcriptomic Deconvolution in Cancer
With over 40 deconvolution methods now available, choosing the right tool has become its own challenge. Our Nature Reviews Cancer review grew from a shared frustration with this problem, and a genuine desire to build a practical roadmap for the field. Here's the story behind it.
Competitive Intelligence as a Dynamic Capability for Organizational Resilience
In an era of hypercompetition, shocks are no longer exceptions. They are the operating condition.
Our recent open-access paper in Review of Managerial Science proposes a conceptual shift that may be useful for scholars working on strategy, intelligence, resilience, and dynamic capabilities.
The safety and efficacy of bispecific T-cell engagers (TCEs) in patients with glioma
Glioblastoma (GBM) is a highly aggressive brain tumor with limited treatment options and poor prognosis. Bispecific T-cell engagers (TCEs) offer a promising immunotherapy approach by redirecting T cells to tumor antigens, and this review highlights their progress and challenges in glioma treatment.
