Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
NTRK activation in cancer is more than fusions
TRK inhibitors have had some of the most remarkable clinical impacts for patients with tumours driven by oncogenic gene fusions in the TRK genes. But are there other structural variants involving the TRKs that drive cancer? Can these also be targeted by TRK inhibitors?
COMPOSER-LLM: Giving AI the Power to Understand the Story Behind Sepsis and Save Lives
We developed COMPOSER-LLM, an AI system that dives into doctors' notes to spot sepsis earlier, showing how language models can boost life-saving predictions in busy hospitals.
Behind the Paper: Potent antagonist for the MAS-related G protein-coupled receptor and its mouse ortholog with anti-inflammatory, anti- asthmatic, and anti-anaphylactic efficacy in human mast cells and mice
This is the story behind the paper by Al Hamwi et al., recently published in Signal. Transduct. Target. Ther. 2025, 10, 128. doi: 10.1038/s41392-025-02209-8.
