Behind the Paper

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Pedigree analysis of a POLD1 germline mutation in urothelial carcinoma shows a close association between different mutation burdens and overall survival

We found a bladder cancer family in which germline mutations of POLD1 and somatic mutations of FGFR3 were prevalent. We studied the changes in the immune microenvironment in patients with this mutation in our cohort and a TCGA cohort and predicted the prognosis of patients with this subtype.
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Yu Xiao and 3 others
Oct 10, 2024