Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
cfDNA dynamics decipher mechanism of action of Ibrutinib in patients with MCL
We investigated cfDNA dynamics prior to and during induction treatment of patients with MCL treated within the TRIANGLE trial and showed an early and superior disease clearance when treated with Ibrutinib and hints toward improved disease clearance in lymph nodes than using chemotherapy
The architectonics of cancer tissue: a “bulk” analytical framework to study cancer tissue organization
Solid tumors are diagnosed by histopathology, which recognizes abnormal tissue architecture. We asked whether these changes are random or follow recurring rules. Using large-scale bulk RNA-seq, we derived quantitative “architecture” signatures that stratify cancers and link to prognosis.
