Behind the paper: ADNP is essential for sex-dependent hippocampal neurogenesis, through male unfolded protein response and female mitochondrial gene regulation
Surprisingly, dramatically different molecular pathways regulate adult neurogenesis in males and females. Importantly, these pathways are strongly impacted by the major autism/intellectual disability gene, ADNP and corrected by the ADNP neuroprotective site, the investigational drug davunetide.