Multi-omics-related tool for patient stratification and prediction of clinical outcome in epigenetically-based CTLA-4 therapy
Metabolic rewiring of the probiotic bacterium Lacticaseibacillus rhamnosus GG contributes to cell-wall remodeling and antimicrobial production
Tissue wasting occurs frequently in patients with advanced cancer. Here, researchers show that the vasculature in adipose tissue responds to tumor-secreted factors by the release of soluble molecules (so called angiokines) acting in a paracrine manner to amplify wasting of white adipose tissue.
Oncometabolite D-2-hydroxyglutarate—dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia
Cancer cachexia is characterized by weight loss and skeletal muscle wasting. The up-regulation of catabolism and down-regulation of anabolism result in concometabolite accumulation. This study focused on genetic mutation-mediated metabolic reprogramming in cancer cachexia progression.