Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Epigenetic immunomodulation to improve the efficacy of cancer immunotherapy: a long-standing path
Multi-omics-related tool for patient stratification and prediction of clinical outcome in epigenetically-based CTLA-4 therapy
How the vasculature controls adipose tissue wasting in cancer cachexia
Tissue wasting occurs frequently in patients with advanced cancer. Here, researchers show that the vasculature in adipose tissue responds to tumor-secreted factors by the release of soluble molecules (so called angiokines) acting in a paracrine manner to amplify wasting of white adipose tissue.
Oncometabolite D-2-hydroxyglutarate—dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia
Cancer cachexia is characterized by weight loss and skeletal muscle wasting. The up-regulation of catabolism and down-regulation of anabolism result in concometabolite accumulation. This study focused on genetic mutation-mediated metabolic reprogramming in cancer cachexia progression.
