Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma
Tracking down targets of the oncogenic epigenetic regulator C-terminal Binding Protein in a mouse pancreatic cancer (PDAC) model led us to ErbB3, highly expressed in up to 60% of PDAC, and the possibility for precision therapy in ErbB3+ PDAC using FDA-approved or novel anti-ErbB2/3 agents.
Despite the rich coordination chemistry, hydroxylamines are rarely used as ligands for transition metal coordination compounds. Here we designed macrocyclic poly-N-hydroxylamines (crown-hydroxylamines) that form complexes containing a d-metal ion and coordinate by up to six hydroxylamine fragments.
In this study, malaria parasite genetic surveillance was undertaken using targeted nanopore sequencing on portable MinION devices in Ghana. The end-to-end process, from sampling to sequencing to data analysis, was performed using laptop computers at two sites in Ghana, one urban and one rural.
“A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells”.
In this paper published in Cellullar & Molecular Immunology by Martín-Cruz L/Viñuela M et al (doi:10.1038/s41423-023-01096-6), we uncover novel molecular mechanisms by which heparan sulfate-related structures associated with tumor cells promote the generation of functional Tregs in cancer.
Pakistan is a typical arid region where enhanced rainfall is more likely to cause floods. New research shows that the Middle East warming is increasing Pakistan's exposure to such disasters.