A low-latitude loess profile from China revealed the dominant ~20,000-year cycle in rainfall change in the core zone of the East Asian summer monsoon, driven by variation in insolation controlled by precession, and precipitation and temperature variation may not follow the same orbital-scale cycles.
Fatalities at railroad crossings decreased by several hundred (2007-2022), attributable in part to Federally-mandated train horns at crossings. Yet sleep disturbance from railway noise contributes significantly to the burden of disease, causal to thousands of disability-adjusted life years (DALY).
Prolonged indoleamine 2,3-dioxygenase-2 (IDO2) activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection(PASC, or long COVID)
CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity
We sought to understand the molecular basis underlying the metabolic flexibility of activated CD8+ T cells, with particular focus on the Cap-Binding Complex adaptor protein ARS2. In doing so, we uncovered a novel link between CD28 costimulation, ARS2, alternative splicing, and anti-tumor immunity.
Molecular Analysis of Pseudomonas aeruginosa Isolates with Mutant gyrA Gene and Development of a New Ciprofloxacin Derivative for Antimicrobial Therapy