Double Boron–Oxygen-Fused Polycyclic Aromatic Hydrocarbons: Skeletal Editing and Applications as Organic Optoelectronic Materials
The development of chemically diverse boron-oxygen-fused polycyclic aromatic hydrocarbons has been limited by their synthetic complexity. Here, authors report a one-pot strategy for their facile synthesis and demonstrate their potential as ultralong afterglow and host materials for deep-blue OLEDs.
Emerging maturation stage-associated markers predict AML subtype vulnerability to cardiac glycosides: a step towards their repurposing?
A new marker associated with AML maturation predicts the AML blast response to cardiac glycosides, a class of agents used for treating arrhythmia but still waiting for a repurposing opportunity in cancer, and identifies approved regimens that would benefit from the addition of these drugs.
Unusually low oxygen and acidified water found in a high seas fishable area of the Pacific Arctic Ocean – A priority area of marine environmental and ecosystem monitoring for potential high seas fisheries –
CDK4/6 inhibitors vs. weekly paclitaxel for ER+/HER2- advanced breast cancer with impending or established visceral crisis
In this retrospective study, patients with ER+/HER2- advanced breast cancer and impending or established visceral crisis had better outcomes when treated with a CDK4/6 inhibitor + endocrine therapy compared to weekly paclitaxel.
Deep learning-enabled realistic virtual histology with ultraviolet photoacoustic remote sensing microscopy
A new laser-based scanning technology shows the capability to image fresh tissues with histological realism and with the speed and resolution needed for intra-operative analysis of resected tissues.