Behind the Paper

The real stories behind the latest research papers, from conception to publication, the highs and the lows

Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma

Tracking down targets of the oncogenic epigenetic regulator C-terminal Binding Protein in a mouse pancreatic cancer (PDAC) model led us to ErbB3, highly expressed in up to 60% of PDAC, and the possibility for precision therapy in ErbB3+ PDAC using FDA-approved or novel anti-ErbB2/3 agents.
Go to the profile of Steven Grossman +1
Steven Grossman and 1 other
Nov 24, 2023


Despite the rich coordination chemistry, hydroxylamines are rarely used as ligands for transition metal coordination compounds. Here we designed macrocyclic poly-N-hydroxylamines (crown-hydroxylamines) that form complexes containing a d-metal ion and coordinate by up to six hydroxylamine fragments.
Go to the profile of Alexey Sukhorukov
Nov 24, 2023