Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma
Tracking down targets of the oncogenic epigenetic regulator C-terminal Binding Protein in a mouse pancreatic cancer (PDAC) model led us to ErbB3, highly expressed in up to 60% of PDAC, and the possibility for precision therapy in ErbB3+ PDAC using FDA-approved or novel anti-ErbB2/3 agents.
Crown-hydroxylamines
Despite the rich coordination chemistry, hydroxylamines are rarely used as ligands for transition metal coordination compounds. Here we designed macrocyclic poly-N-hydroxylamines (crown-hydroxylamines) that form complexes containing a d-metal ion and coordinate by up to six hydroxylamine fragments.
Malaria genomic surveillance using nanopore sequencing: Shifting the focus into endemic countries
In this study, malaria parasite genetic surveillance was undertaken using targeted nanopore sequencing on portable MinION devices in Ghana. The end-to-end process, from sampling to sequencing to data analysis, was performed using laptop computers at two sites in Ghana, one urban and one rural.
“A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells”.
In this paper published in Cellullar & Molecular Immunology by Martín-Cruz L/Viñuela M et al (doi:10.1038/s41423-023-01096-6), we uncover novel molecular mechanisms by which heparan sulfate-related structures associated with tumor cells promote the generation of functional Tregs in cancer.
Rainfall is increasing on the edges of the South Asian Monsoon
Pakistan is a typical arid region where enhanced rainfall is more likely to cause floods. New research shows that the Middle East warming is increasing Pakistan's exposure to such disasters.
