AUTHORS: Aurélie Blanfuné, Charles-François Boudouresque, Marc Verlaque, Antoine Minne, Fanny Noisette, Thierry Thibaut
Analyzing effects of vitro expansion on the methylome of chimeric antigen receptor (CAR) T cells revealed loci with increased methylation that were also associated with reduced long-term survival in patients. These findings suggest that reduced cultivation periods may benefit clinical outcome.
Behind-the-scenes, nostalgic rambling on the synthesis and completion of "LY6E is a pan-coronavirus restriction factor in the respiratory tract."
How is the identity of a cell encoded in its genome? And what underlies transcriptomic changes in disease states? SCENIC+ helps researchers provide answers to these questions (and many more … ) by inferring enhancers and gene regulatory networks.