Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Rescuing retromer in Parkinson's disease
Both Vp35 p.D620N and LRRK2 pathogenic variants cause late-onset, familial Parkinson's disease. In vivo, we show Vps35 p.D620N activates LRRK2 kinase activity, impairs the recycling and physiologic function of the dopamine transporter (DAT), and can be rescued by LRRK2 kinase inhibitors.
Digital Haptics for Navigating without Vision
How could we learn and navigate through spaces without using vision? Digital haptic technologies may be an alternative and new technologies are making this a reality.
A review of foot-and-mouth disease in Ethiopia: epidemiological aspects, economic implications, and control strategies
Foot-and-mouth disease (FMD) is one of the most devastating animal diseases in the world. It affects the health and productivity of cloven-hoofed animals such as cattle, sheep, goats, pigs, and wildlife.
The Grinch got big for us with no physical consequences. But how do we prevent aneurysms from rupturing in real life?
They say that the Grinch’s heart grew three sizes in one day. In the land of fantasy, this makes him a happier person and a friendlier neighbor to the Whos. In real life, rapid cardiovascular expansion is a silent but deadly disease.
Staphylococcus aureus functional amyloids catalyze degradation of β-lactam antibiotics
Bacterially secreted amyloid fibrils were shown for the first time to catalyze the degradation of β-lactam antibiotics. This observation points to possible antibiotic resistance mechanisms associated with bacterial biofilms.
