Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Breakthrough in Stereoselective C(sp³)–H Alkylation: Nickel Catalysis Unlocks Efficient Synthesis of Chiral Heterocycles
The Kong group report a Ni-catalyzed enantioselective C(sp³)–H alkylation of saturated heterocycles using olefins, enabling efficient construction of chiral C(sp³)–C(sp³) bonds. Applications include late-stage drug diversification and concise syntheses of bioactive alkaloids.
The jet stream, floods, and droughts in Central Europe: A six-hundred year perspective
New 3-dimensional climate reconstructions allow studying the variability of the Atlantic-European jet stream back to the 15th century. The analysis shows that extreme climate events were related to excursion in the jet.
Visualizing 3D neuroskeletal interactions in the skull
This study investigates the impact of aging on the neurovascular architecture of the murine skull. We identified unique changes in neurovascular distribution and interactions thanks to our 3D imaging platform. Here, I share this study's challenges and resulting future outlook.
