Organoids—three-dimensional structures derived from stem cells—are transforming biomedical research by modeling key aspects of human physiology and disease. By replicating native tissue architecture, cellular heterogeneity, and functional behavior, they provide human-relevant systems that address limitations inherent to conventional in-vitro and animal models.

Diabetes and cardiovascular disease are deeply interconnected conditions, characterized by shared, multi-organ pathophysiology. Organoid technologies offer unique opportunities to dissect disease mechanisms, evaluate therapeutic strategies, and develop personalized, physiologically relevant models. These systems enable the investigation of cardiometabolic processes in platforms that better reflect the complexity and progression of human disease.

Cardiovascular Diabetology welcomes original research articles, reviews, and meta-analyses for this Collection, which aims to highlight the use of organoid technologies in advancing our understanding of cardiovascular complications associated with diabetes.

Areas of interest include, but are not limited to:

- Organoid models of diabetic cardiomyopathy and heart failure

- Matrigel alternatives for organoid development

- Cell-cell and extracellular matrix interactions in organoids

- Organoid-based drug testing for cardiovascular diseases

- Organoid-on-chip systems for tissue crosstalk and perfusion3D bioprinting and tissue engineering for cardiovascular organoids

- Artificial intelligence–driven analysis of organoid function and phenotypes

- Organoid models of gestational diabetes–induced congenital heart disease

- Functional genomics using CRISPR in cardiovascular organoids

- Single-cell and spatial omics to map disease states in organoids

- Co-culture systems of vascular and pancreatic organoids to study metabolic-vascular crosstalk

- Organoid-based screening platforms for anti-diabetic and cardioprotective drugs

Submissions that contribute to conceptual clarity (e.g., distinctions between organoids and spheroids), incorporate multi-organ or metabolic system perspectives, or connect technological development with clinical or translational insights are especially welcome.

This Collection supports and amplifies research related to SDG 3, Good Health and Well-Being.

All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email OAfundingpolicy@springernature.com or the Editor-in-Chief.

BMC Oral Health is pleased to announce our upcoming Collection on Systemic disease and oral health. The interrelationship between systemic diseases and oral health has garnered increasing attention in recent years. Research has shown that conditions such as diabetes, cardiovascular disease, and respiratory illnesses can significantly impact oral health, while poor oral health can exacerbate systemic diseases. This Collection aims to explore the multifaceted connections between systemic health and oral conditions, emphasizing the importance of an integrated approach to healthcare that recognizes the bidirectional nature of these relationships. We invite researchers to contribute studies that investigate the mechanisms underlying these connections and their implications for clinical practice.

Continued exploration in this field could yield significant advancements in personalized healthcare approaches, leading to more effective prevention and treatment strategies. Building on the contributions from our previous Collection, Oral and systemic health, we aim to enhance our understanding of how systemic diseases influence oral health. We may also uncover new strategies for early diagnosis and interventions tailored to individual patient profiles.

We invite submissions on a range of topics that include but are not limited to:

- The impact of diabetes on oral health

- Cardiovascular disease and periodontal disease connections

- Respiratory disease and oral health implications

- Oral health in patients with rheumatoid arthritis

- The role of oral health in cancer treatment outcomes

All manuscripts submitted to this journal, including those submitted to collections and special issues, are assessed in line with our editorial policies and the journal’s peer-review process. Reviewers and editors are required to declare competing interests and can be excluded from the peer review process if a competing interest exists.