Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Mitochondria chaperone-mediated stability of SIX1 opens a door for prostate cancer progression and castration resistance
This work shows how mitochondria chaperone GRP75 regulates the stability of SIX1, a transcription factor for embryonic development and cancer progression. Our findings provide important insights into the protein degradation mechanism as well as a novel avenue for prostate cancer therapy.
Climate Change and Peatlands: Increased Non-growing Season Emissions
Using 13 years of Eddy Covariance CO2 flux measurements at a temperate peatland, we predict that future climate warming will increase non-growing season net ecosystem exchanges of CO2, with greater CO2 emissions resulting from increases in radiative forcing.
Target cancer-associated fibroblasts to potentiate PARP inhibitors
Besides eradicating tumour cells with deficiencies for homologous recombination, PARP inhibitors can induce the activation of CAFs within the TME via NF-κB/CCL5 pathway. CCL5 blockade blunts the reprogramming of CAFs conditioned by PARP inhibitors and potentiates PARP inhibitors.
Influence of static disorder of charge transfer state on voltage loss in organic photovoltaics
Disorder in the energies of charge-transfer (CT) states can be induced by the complex phase behaviour of bulk heterojunctions in organic semiconductors. Here, we propose a model to help to quantify and understand the impact of CT state energetic disorder on voltage losses in organic photovoltaics.
In bacteria-phage ecology and evolution, community context matters
Our understanding of the ecology and evolution of bacteria and their viruses, bacteriophages, in multispecies contexts is limited. A new review paper summarizes what little we know and highlights the many open questions that remain.
