Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Conducting CRISPR/dCas9 screens to identify drug resistance mechanisms in neuroblastoma
To wait for resistance to drugs to develop in patients and then identify why it happened, will lead to a deadly lag in the design of salvage therapies or indeed preventative treatment approaches.
The search for a better protein marker of autophagy
Measuring ATG16L1 phosphorylation as an alternative method to monitor autophagy induction
Beyond the DNA sequence of Clostridioides difficile
Winter 2014, I was revising a grant proposal to develop methods for characterizing bacterial methylomes, the collective DNA methylation events beyond the four canonical bases, G, A, T and C.
