Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Procyanidin C1 is a natural agent with senolytic activity against ageing and age-related diseases
Advancements of studies with model organisms that cellular senescence drives ageing and age-related pathologies have elicited widespread efforts to identify compounds of a potential to selectively kill senescent cells, now termed as 'senolytics'.
Microgravity and bone physiology: Impacts on skeletal stem/progenitors.
Our paper entitled “Transcriptional responses of skeletal stem/progenitor cells to hindlimb unloading and recovery correlate with localized but not systemic multi-systems impacts” just published in npj Microgravity, reveals how simulated microgravity alters bone at the stem/progenitor level.
Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer
In this clinical study, we have validated a 44 gene expression based DDIR signature as a predictor of response to neoadjuvant chemotherapy in breast cancer, which can be integrated into clinical workflows, and potentially identifies a subgroup of cancers responsive to anthracycline treatment.
Suppression of common species enables bacterial rarity in dry soils
A chosen few, common species are globally widespread. On the other hand, rare bacterial species display high sensitivity to environmental conditions at low relative abundances. Predictable shifts in soil bacterial rarity occur across biomes primarily driven by soil hydration conditions.
