Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells
This post details some of the motivation and concepts of our paper, and why we decided to focus on a different type of observable phenotype within CRISPR genetic screens.
Two-input protein logic gate for biological computation
Here we design a two-input single protein logic gate for biological computation by allosterically wiring two inputs to a functional site of a protein.
Fine-tuning mechanism of "body building" in space microgravity environment with epigenetic modifications
Our paper entitled "Histone deacetylase HDA-4-mediated epigenetic regulation in space-flown C. elegans” just published in npj Microgravity, demonstrates a novel epigenetic modification in response to microgravity environment of space-grown C. elegans.
Sparse deconvolution: one decisive step into computational fluorescence superresolution
We stumble upon an iterative optimization of fluorescence images followed by the RL deconvolution using the spatiotemporal continuity and sparsity prior knowledge. This Sparse deconvolution algorithm can extend spatial resolutions of fluorescence microscopes beyond their hardware constraints.
