Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Biomedical Research
Deubiquitylase USP52 Promotes Bladder Cancer Progression by Modulating Ferroptosis through Stabilizing SLC7A11/xCT
We identified USP52 as a DUB that cleaves K48-linked ubiquitin at K4 and K12 of xCT. Loss of USP52 reduces cell proliferation by decreasing xCT and enhancing ferroptosis sensitivity. Combining USP52 depletion with IKE strongly inhibits BLCA progression, presenting a new potential therapy.
Exploring the Connection Between the Oral Microbiome and Mental Health
A new study published in Translational Psychiatry examined the oral-brain connection by studying the salivary microbiome in individuals with various mental health symptoms compared to those without, in the context of their periodontal health.
Fat and liver health: the view from LXRalpha
Fat accumulation in the liver is a defining feature of metabolic dysfunction associated steatotic liver disease and reduction of liver triglyceride is a major therapeutic goal. We show that a key driver of lipogenesis called LXRalpha may actually protect the liver by lowering liver cholesterol.
Preliminary Phase 2a Readout for a Novel Drug Discovered and Designed Using Generative AI Sets a Major Milestone in AI-Powered Drug Discovery
Insilico Medicine’s AI-Designed Small Molecule Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis Yields Positive, Promising Phase 2 Trial Data
A promising nanotechnology to unlocking bladder cancer treatment
A non-invasive full-course NIR-II fluorescence imaging-navigated on-demand therapeutic strategy has been established with promises to optimize the treatment paradigm for bladder cancer.
Antibodies need teamwork!
We develop a novel approach to identify anti-bacterial antibodies from human B cells and reveal that some antibodies can act synergistically
