Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Biomedical Research
MSK-CHORD: an AI-enabled, 24,950-patient clinicogenomic dataset for cancer research
AI annotation, tumor genomic profiling, and combination of other siloed datasets enables creation of a clinicogenomic, harmonized oncologic real-world dataset (MSK-CHORD). MSK-CHORD allows for study of cancer genotype-phenotype relationships at a scale previously impossible.
Epigenetic modulation via the C-terminal tail of H2A.Z
The histone tail, as part of the endogenous H2A.Z, or added in excess to nuclei/cells, exerts a large effect on nucleosome stability as well as on nuclear architecture, and its alternative molecular engagements explain the intranuclear heterogeneity of the H2A.Z-nucleosomes in vivo.
Unlocking a Detrimental Role of IGF1 in Osteoarthritis: A New Target for Therapeutic Intervention?
Osteoarthritis is a common joint disease that leads to pain, stiffness and limited mobility, for which no effective treatments are available. My team and I, driven by the desire to address this medical need, studied the biology of cartilage and this led us to uncover a surprising player in OA: IGF1.
