Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Biomedical Research
It is time for a global ban of declaw in cats
I graduated as a veterinarian in Lyon, France, in 1992 — the very year the European Union banned declawing cats. When I later arrived in North America to specialize in anesthesia and pain management, I was shocked to see how common this procedure still was. I had never even learned how to do it.
Alcohol Blocks Gut Immune Gatekeepers, Compromising Defense Against Bacteria in ALD
mAChR4 -regulated goblet cell–associated antigen passages (GAPs) train gut immune cells, acting as sentinels, maintaining antimicrobial defense in the gut-liver axis, and positioning mAChR4 agonism and GAP formation as a therapeutic checkpoint for alcohol-associated liver disease (ALD).
RNA structure beyond canonical base pairs guided by evolution
This is a novel method that integrates the prediction of RNA secondary structure with that of RNA 3D motifs. RNA 3D motifs steer the assembly of canonical helices into a 3D structure. Fully integrated prediction of 3D motifs together with base pairs is a vital step toward inferring RNA 3D structure.
Bringing Exposure-Related Malnutrition (ERM) to the Scientific Stage
Patients can appear well-nourished yet show fatigue, slow recovery, and early decline. Our work defines Exposure-Related Malnutrition (ERM) — a hidden, reversible state where chronic stress and exposures divert nutrients from repair to survival, accelerating biological aging.
The impact of autoimmune co-morbidities in AQP4-NMOSD and MOGAD.
Aquaporin-4 neuromyelitis optica spectrum disorder (AQP4-NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) can present similarly to Multiple Sclerosis (MS) but presents with unique therapeutic and prognostic challenges.
Immobilized acyl-transfer molecular reactors enable the solid phase synthesis of sterically hindered peptides
An immobilized ribosome-mimicking molecular reactor (RMMR) boosts coupling efficiency in the solid-phase synthesis of N-methylated or α,α-disubstituted amino acid(s)-containing sterically hindered peptides, including cyclosporin A and alamethicin F analogues.
