Spatial multi-omics analysis in single cells for precision oncology
Multiplex bioimaging of single-cell profiles in patient biopsies and artificial intelligence analysis of spatially distinct patient cohorts inform personalized cancer treatments.
MET-N375S: A therapeutically-actionable germline polymorphism in Asian cancer patients
We found that the most common polymorphism known to affect the MET gene (Asn375Ser [N375S]) increases the aggressiveness of squamous cell carcinoma of the lung, head and neck, and is unexpectedly amenable to HER2 blockers but resistant to c-Met inhibitors.
A stress response pathway promotes immune evasion in lung cancer
Using CRISPR based screening, we discovered that activation of the integrated stress response pathway enhances PD-L1 translation and promotes immune suppression in lung cancer.
