ARID1A’s role in lineage plasticity and therapeutic response in breast cancer
We uncover a critical role for ARID1A in maintaining luminal cell identity and endocrine therapy response in ER+ breast cancer.
The Peter Pan syndrome: stalled development in pediatric brain tumors
We use a data-driven approach to identify cell of origin in several pediatric brain tumor entities, and show that tumor gene expression programs are consistent with stalled differentiation of the corresponding normal lineages
Reversing cancer immune exclusion with PAK4 inhibition
Gabriel Abril-Rodriguez and Antoni Ribas