Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Neuroscience
A potential patient stratification biomarker for Parkinson's disease based on LRRK2-mediated cellular alterations in peripheral blood
A recent study substantiates a role for increased LRRK2 kinase activity in some idiopathic Parkinson's disease patients and suggests that blood-based patient stratification approaches hold promise in nominating patients who may benefit from LRRK2-related therapeutics.
The collaboration behind a study on COVID-19 neurological complications
"Alone we can do so little; together we can do so much.” –Helen Keller.
Differences in rectal amino acid levels determine bacteria-originated sex pheromone specificity in two closely related flies
Bactrocera dorsalis is a notorious invasive species. Along with it, its "cousin" Bactrocera cucurbitae, has a similar morphological and sexual pheromone composition. So, why they can avoid mating with their "cousins"? Amino acid， glucose，bacteria，which is the decisive factor?
Why rats (and humans) addicted to alcohol may not respond to psilocybin treatment
In our paper, we show how severity of alcohol relapse in rats can affect psilocybin’s mode of action
Rescuing retromer in Parkinson's disease
Both Vp35 p.D620N and LRRK2 pathogenic variants cause late-onset, familial Parkinson's disease. In vivo, we show Vps35 p.D620N activates LRRK2 kinase activity, impairs the recycling and physiologic function of the dopamine transporter (DAT), and can be rescued by LRRK2 kinase inhibitors.
Digital Haptics for Navigating without Vision
How could we learn and navigate through spaces without using vision? Digital haptic technologies may be an alternative and new technologies are making this a reality.
