Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Deubiquitylase USP52 Promotes Bladder Cancer Progression by Modulating Ferroptosis through Stabilizing SLC7A11/xCT
We identified USP52 as a DUB that cleaves K48-linked ubiquitin at K4 and K12 of xCT. Loss of USP52 reduces cell proliferation by decreasing xCT and enhancing ferroptosis sensitivity. Combining USP52 depletion with IKE strongly inhibits BLCA progression, presenting a new potential therapy.
DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC
Based on the bladder cancer (BLCA) pedigree containing germline mutation of POLD1 found in our last study, we further analyzed the molecular role of POLD1 driving tumorigenesis. We identified POLD1 as a promotor of BLCA via a MYC driven mechanism.
Behind the Scenes of the "Quality of Life and Social Change" Handbook
This handbook offers a holistic roadmap to improve individual and collective well-being. Rooted in the POZE paradigm, it explores the interconnectedness of individuals, communities, and the planet, offering practical insights for fostering sustainable, meaningful social change.
New study explores survival strategies by invasive macroalgae and native limu in spring-fed nearshore ecosystems
In this project, University of Hawaiʻi at Mānoa botanists measured survival of invasive macroalgae and limu (Hawaiian macroalgae) in brackish nearshore springs (submarine groundwater discharge, SGD), where the tidal cycle drives extreme daily fluctuations in salinity.
Pedigree analysis of a POLD1 germline mutation in urothelial carcinoma shows a close association between different mutation burdens and overall survival
We found a bladder cancer family in which germline mutations of POLD1 and somatic mutations of FGFR3 were prevalent. We studied the changes in the immune microenvironment in patients with this mutation in our cohort and a TCGA cohort and predicted the prognosis of patients with this subtype.
