Behind the Paper

The real stories behind the latest research papers, from conception to publication, the highs and the lows

Cellular & Molecular Immunology
Behind the Paper

Behind the Paper: How IL-6 shapes the anti-tumor battle and supports TGFβ immune modulatory vaccines in pancreatic cancer

The study highlights that the antitumor efficacy of TGFβ-specific T cells in pancreatic cancer critically depends on IL-6 signaling. IL-6R blockade compromises the immune response by reducing vaccine-induced T-cell infiltration as well as increasing immunosuppressive tumor-associated macrophages.
Go to the profile of Mads Hald Andersen +1
Mads Hald Andersen and 1 other
Dec 17, 2024

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