Behind the Paper

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Behind the Paper

Amphiphilic peptide Mastoparan-B induces conformational changes within the AdeB efflux pump, down-regulates adeB gene expression, and restores antibiotic susceptibility in an MDR strain of Acinetobacter baumannii

A series of computer-based experiments was done to find the mechanism antiefflux activity of MP-B against the MDR strain of A. baumannii (AB). We generated 20 poses of apo-MP-B using the InterPep tool. Analysis revealed that apo MP-B formed H-bonds to the backbone of five amino acids in Helix-5.
Go to the profile of Professor Mohammad Reza Shakibaie
Professor Mohammad Reza Shakibaie
Oct 01, 2024

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